Polyglutamic Acid Explained

Quick Facts.... Polyglutamic Acid (PGA) is a Humectant and part of the Hydrogel Family

Polyglutamic acid (PGA) has a higher molecular weight than hyaluronic acid, making it exceptionally effective at attracting and retaining moisture in the skin. As a powerful hydrating amino acid, PGA draws in water and locks it in, providing immediate and long-lasting hydration.

PGA acts as a humectant, minimizing moisture loss and supporting the skin’s elasticity. Its plumping effect helps reduce the appearance of wrinkles and fills in under-eye hollows, such as tear troughs and eye bags. Compared to retinol products, polyglutamic acid offers a safer alternative for sensitive skin.

This ingredient also enhances the skin’s natural hyaluronic acid levels and is utilized in pharmaceutical development for drug delivery both inside and outside the body. Lightweight and non-comedogenic, PGA allows other vitamins and minerals applied to the skin to absorb more evenly, improving their effectiveness and longevity. It also extends the benefits of oil-based serums.

Polyglutamic acid is four times more hydrating than hyaluronic acid. Clinical studies on wound healing have shown that PGA supports cell rejuvenation, promotes skin repair, and improves circulation. Ongoing research is exploring its potential in cancer treatments, wound cleansing agents, and tissue regeneration

Polyglutamic acid (PGA) plays a crucial role in supporting the skin’s ability to rebuild its structure by replenishing the fluids necessary for healthy cell function. The PGA content in our Osmotic Hydrating Serum not only addresses areas where moisture is lacking but also enhances the effectiveness of any subsequent topical or transdermal products by ensuring the skin’s deeper layers are well hydrated.

Hydrogels are effective in helping the skin reach optimal hydration levels. Incorporating a daily combination of PGA and hyaluronic acid (HA) can help maintain skin integrity across all age groups, with particular benefits for those with sensitive or problematic skin types.

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References to research and articles:

1. Drug delivery systems https://www.sciencedirect.com/science/article/abs/pii/S1878818122000196 
   
   
2. Versatility in cosmetics https://www.mdpi.com/2079-9284/11/3/76 
   
   
3. Cancer therapy innovations https://www.benthamdirect.com/content/journals/cdd/10.2174/1567201820666230116164511 
   
   
4. Wound healing https://spj.science.org/doi/full/10.34133/bmr.0063 
   
   
5. Polyglutamic acid - study to determine efficacy on eye drops https://www.sciencedirect.com/science/article/pii/S2666893924001579 
   
   
6. Book:
   Title: Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundamentals to Applications by
   J. Miguel Oliveira, Joana Silva-Correia, Rui L. Reis
   Academic Press, 19 Sept 2023
    https://www.sciencedirect.com/book/9780128239483/hydrogels-for-tissue-engineering-and-regenerative-medicine#book-description