Polyglutamic acid (PGA) is a next-generation humectant and a key member of the hydrogel family—an advanced group of compounds known for their exceptional ability to retain moisture. With a molecular weight significantly higher than that of hyaluronic acid, PGA has an extraordinary capacity to attract and lock in water, delivering both instant and long-lasting hydration to the skin.
As a powerful hydrating amino acid, PGA not only draws moisture into the skin but also prevents it from escaping, helping to maintain elasticity and suppleness. Its natural plumping effect smooths fine lines and softens under-eye hollows, such as tear troughs and puffiness. Unlike retinol, which can irritate sensitive skin, polyglutamic acid offers a gentle yet highly effective alternative for those seeking hydration without compromise.
What makes PGA even more remarkable is its ability to enhance the skin’s own hyaluronic acid production while improving the absorption and performance of other active ingredients. Lightweight and non-comedogenic, it allows vitamins, minerals, and oil-based serums to penetrate more evenly and deeply, amplifying their benefits and longevity.
Clinical research has shown that polyglutamic acid is up to four times more hydrating than hyaluronic acid. Studies in wound healing and tissue regeneration highlight its ability to support cell renewal, improve circulation, and accelerate skin repair. Its versatility has even led to exploration in advanced medical applications, including drug delivery systems, wound care, and cancer therapy innovations.
In our Osmotic Hydrating Serum, the inclusion of polyglutamic acid is intentional and evidence-based. It replenishes essential moisture in the deeper layers of the skin, creating the ideal environment for healthy cell function and enhancing the performance of any subsequent skincare or transdermal treatments.
It’s important to note that serums containing polyglutamic acid are rare. This is because formulating with PGA requires a deep understanding of its chemical structure and interactions—knowledge that only comes from true expertise in cosmetic chemistry. Many brands overlook this ingredient simply because they don’t fully grasp its potential. Our use of PGA demonstrates not only scientific precision but also our commitment to staying ahead of the curve in skincare innovation.
Hydrogels like PGA help the skin achieve optimal hydration balance. When combined daily with hyaluronic acid, they work synergistically to maintain skin integrity across all ages and skin types, offering particular benefits for those with sensitive or reactive skin.
References:
Drug delivery systems – sciencedirect.com
Versatility in cosmetics – mdpi.com
Cancer therapy innovations – benthamdirect.com
Wound healing – spj.science.org
Polyglutamic acid efficacy in eye drops – sciencedirect.com
Book: Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundamentals to Applications by J. Miguel Oliveira, Joana Silva-Correia, Rui L. Reis – Academic Press, 2023